龚其海
一、个人简介
龚其海，医学博士、二级天下足球网，兼职博士研究生导师。贵州省优秀青年科技人才，贵州省高层次创新人才“百”层次人才，教育部新世纪优秀人才，贵州省省管专家。现任贵州省基础药理重点实验室、基础药理教育部重点实验室暨特色民族药教育部国际合作联合实验室主任，贵州省中药民族药2011协同创新中心主任，中国药理学会第十二届理事会理事，中国药理学会中药与天然药物药理专业委员会委员，《中药药理与临床》编委，《遵义医科大学学报》副主编。
研究方向为中药药理学与毒理学，先后完成贵州道地中药材淫羊藿、天麻主要有效成分淫羊藿苷、天麻素等用于防治老年痴呆、缺血性脑卒中等的研究及黔产木姜叶柯甜茶综合开发利用关键技术研究。主持（完成）国家重点研发计划、国家自然科学基金等国家级课题5项，省部级项目20项，以第一作者或通讯作者发表SCI论文58篇，已培养硕士30名，在读硕士生9名，博士1名，在读博士生3名。已转让国家发明专利2项，获贵州省科技进步一等奖1项、二等奖2项，三等奖1项。先后获贵州省青年科技奖、贵州省优秀教师、贵州省优秀硕士生导师、中国药学会药学期刊优秀论文奖、中国药理学会SERVIER青年药理工作者奖、西部药学之星、贵州青年“五四”奖章及贵州省优秀党务工作者等表彰，带领的团队先后入选贵州省科技创新人才团队、教育部创新团队（包括“滚动”支持），享受国务院特殊津贴。
二、代表性成果
1. Jianmei Gao, Congjian Ma, Dianya Xia, Nana Chen, Jianyong Zhang, Fan Xu, Fei Li, Yuqi He, Qihai Gong*. Icariside II preconditioning evokes robust neuroprotection against ischaemic stroke, by targeting Nrf2 and the OXPHOS/NF-κB/ferroptosis pathway. Br J Pharmacol. 2023;180(3):308-329.
2. Jianmei Gao, Xun Zhang, Guotao Shu, Nana Chen, Jianyong Zhang, Fan Xu, Fei Li, Yuangui Liu, Yu Wei, Yuqi He, Jingshan Shi, Qi-hai Gong*. Trilobatin rescues cognitive impairment of Alzheimer's disease by targeting HMGB1 through mediating SIRT3/SOD2 signaling pathway. Acta Pharmacol Sin. 2022, 43: 2482–2494.
3. Yiqi Li, Yeli Li, Nana Chen, Linying Feng, Jianmei Gao , Nan Zeng, Zhixu He, Qihai Gong*.Icariside II Exerts Anti-Type 2 Diabetic Effect by Targeting PPARα/γ: Involvement of ROS/NF-κB/IRS1 Signaling Pathway. Antioxidants (Basel). 2022;11(9):1705.
4. Yeli Li, Linying Feng, Dianyou Xie, Mu Lin,Yiqi Li, Nana Chen, Danli Yang, Jianmei Gao,Yizhun Zhu, QihaiGong*. Icariside II, a naturally-occurring SIRT3 agonist, rescues myocardial infarction through AMPK/PGC-1α/apoptosis signaling pathway. Antioxidants (Basel). 2022;11(8):1465.
5. Fengying Huang, Lingyu Luo, Yujia Wu, Dianya Xia, Fan Xu, Jianmei Gao, Jingshan Shi, Qihai Gong*.Trilobatin promotes angiogenesis after cerebral ischemia-reperfusion injury via SIRT7/VEGFA signaling pathway in rats. Phytother Res. 2022;36(7):2940-2951.
6. Li Na, Li Xi, Shi Yan-Ling, Gao Jian-Mei, He Yu-Qi, Li Fei, Shi Jing-Shan, Gong Qi-Hai*.Trilobatin, a Component from Lithocarpus polystachyrus Rehd., Increases Longevity in C. elegans Through Activating SKN1/SIRT3/DAF16 Signaling Pathway. Front Pharmacol . 2021;12:655045.
7. Jianmei Gao, Long Long, Fan Xu, Linying Feng,Yuangui Liu, Jingshan Shi, Qihai Gong*. Icariside II, a phosphodiesterase 5 inhibitor, attenuates cerebral ischemia/reperfusion injury by inhibiting GSK-3β-mediated activation of autophagy. Br J Pharmacol. 2020 Mar;177(6):1434-1452.
8. Jianmei Gao, Wei Wang, Na Li, Nana Chen, Fan Xu, Jingshan Shi, Qihai Gong*.Neuroprotective effects of trilobatin, a novel naturally-occurring Sirt3 agonist from Lithocarpus polystachyus Rehd., mitigates cerebral ischemia/reperfusion injury: Involvement of TLR4/NF-κB and Nrf2/ Keap-1 signaling. Antioxid Redox Signal. 2020;33(2):117-143.
9. Yong Zheng, Yan Deng, Jian-Mei Gao, Chun Lv, Ling-Hu Lang, Jing-Shan Shi, Chang-Yin Yu*, Qi-Hai Gong*.Icariside II inhibits lipopolysaccharide-induced inflammation and amyloid production in rat astrocytes by regulating IKK/IκB/NF-κB/BACE1 signaling pathway. Acta Pharmacol Sin. 2020 Feb;41(2):154-162.
10. Mu-Bo Liu, Wei Wang, Jian-Mei Gao, Fei Li, Jing-Shan Shi, Qi-Hai Gong*.Icariside II Attenuates Cerebral Ischemia/Reperfusion-Induced Blood-Brain Barrier Dysfunction in Rats via Regulating the Balance of MMP9/TIMP1. Acta Pharmacol Sin. 2020 ;41(12):1547-1556.