郭大乐
一、个人简介
郭大乐，博士，副天下足球网，硕士研究生导师，四川省分析测试学会有机质谱专业委员会委员。2016年毕业于中国科学院成都生物研究所药物化学专业，主要从事中药（及其内生菌）活性成分发现的相关研究。包括基于树脂、凝胶、反相硅胶、手性填料对次生代谢产物进行光学纯级别制备；基于核磁共振、高分辨质谱、光谱（ECD，OR，NMR）计算、诱导CD、单晶衍射及常见的解衍生化反应（如Marfey法、Mosher法）等物理化学技术手段对天然产物的绝对构型进行解析；基于细胞、动物、植物模型对化合物的生物活性及作用机制进行评估和阐述。截止目前主持国家自然科学基金、四川省科技计划项目、中国博士后科学基金等八项课题；并以通讯作者或第一作者身份在Journal of Natural Products，Phytochemistry，Journal of Agricultural and Food Chemistry，Bioorganic Chemistry等业内权威期刊发表SCI论文30余篇。
e-mail：guodale@cdutcm.edu.cn
二、代表性成果（可含承担项目、发表论文、论著、获奖等）
承担项目（主持）
1. 国家自然科学基金委员会，青年科学基金项目，82204603，基于“单细胞转录组测序-HTS2高通量筛选”联用新策略的地榆治疗溃疡性结肠炎药效物质基础研究，2023/01-2025/12，30万元，在研；
2. Syngenta，PhD & Postdoc Programme，Searching Bioactive Natural Products from Traditional Chinese Medicines in Southwest China，2022/10-2026/10，40 000 USD，in study (co-PI)；
3. 天下足球网，“杏林学者”学科人才科研提升计划—苗圃人才专项，MPRC2021007，基于“肝肾同源，精血互化”理论的地榆靶向c-Mpl促血小板生成的物质基础及机制研究，2021/07-2024/07，12万元，在研；
4. 四川省科学技术厅，四川省科技计划项目（重点研发项目），2021YFN0134，中药内生菌源生物农药的创制及共性关键技术的研发与示范：以从岩白菜内生菌次生代谢产物中开发新型农用抗生素为例，2021/04-2024/03，30万元，在研；
5. 中国博士后科学基金会，面上项目，2017M622985，基于基因表观修饰技术获取川芎内生菌抑制血管生成物质，2018/01-2019/12，5万元，已结题。
发表论文（标记#为第一作者；标记*为通讯作者）
1. Xinai Li#, Sining Li#, Yu Jiang, Zhenxing Zheng, Wenxiu Guo, Ran Liu, Guangzhi Wang, Xu Zhang, Qiang Bian, Mingzhi Zhang, Yucheng Gu, Sheng Yin, Dale Guo*, Yun Deng*. Comparative study of characteristic compounds of three species of truffle. Journal of Separation Science, 2023, doi: 10.1002/jssc.202200883.（Online ahead of print）
2. Xueyan Huo#, Lirong Lei#, Wenxiu Guo, Yunjie Hu, Qixuan Kuang, Mengdan Liu, Wan Peng, Yifei Dai, Dong Wang, Yucheng Gu, Dale Guo*, Yun Deng*. Trichodimerol inhibits inflammation through suppression of the nuclear transcription factor-kappaB/NOD-like receptor thermal protein domain associated protein 3 signaling pathway. Frontiers in Microbiology, 2022, 13: 999996.
3. Lijun Huang, Leiqiang Gong, Xueyan Huo, Lirong Lei, Qi Zhang, Yunjie Hu, Qixuan Kuang, Yu Gui, Yifei Dai, Yucheng Gu, Yun Deng*, Dong Wang*, Dale Guo*. N-acetyldopamine dimer inhibits neuroinflammation through the TLR4/NF-B and NLRP3/Caspase-1 pathways. Acta Biochimica et Biophysica Sinica, 2022, doi: 10.3724/abbs.2022116.（Online ahead of print）
4. Qixuan Kuang, Yan Luo, Lirong Lei, Wenxiu Guo, Xinai Li., Yumei Wang, Xueyan Huo, Mengdan Liu, Qi Zhang, Dan Feng, Lijun Huang, Dong Wang, Yucheng Gu, Yun Deng*, Dale Guo*. Hydroanthraquinones from Nigrospora sphaerica and their anti-inflammatory activity uncovered by transcriptome analysis. Journal of Natural Products, 2022, 85(6): 1474–1485.
5. Qixuan Kuang, Lirong Lei, Qingzhou Li, Wan Peng, Yumei Wang, Yifei Dai, Dong Wang, Yucheng Gu, Yun Deng*, Dale Guo*. Investigation of the anti-inflammatory activity of fusaproliferin analogues guided by transcriptome analysis. Frontiers in Pharmacology, 2022, 13: 881182.
6. Qixuan Kuang, Qingzhou Li, Lirong Lei, Yumei Wang, Lijun Huang, Yifei Dai, Wan Peng, Mingzhi Zhang, Dong Wang, Yucheng Gu, Yun Deng*, Dale Guo*. Proliferatins suppress lipopolysaccharide-induced inflammation via inhibition of the NF-κB and MAPK signaling pathways. Bioorganic Chemistry, 2022, 124: 105810.
7. Lijun Huang#, Yumei Wang#, Leiqiang Gong, Chao Hu, Yu Gui, Chen Zhang, Xue Tan, Xiankuo Yu, Yile Liao, Yan Luo, Yuqin Tang, Yifei Dai, Yun Deng*, Dong Wang*, Dale Guo*. N-acetyldopamine dimer attenuates DSS-induced ulcerative colitis by suppressing NF-κB and MAPK pathways. Frontiers in Pharmacology, 2022, 13: 842730.
8. Zhenxing Zheng#, Hanwen Hu#, Li Zeng, Huan Yang, Tianlong Yang, Di Wang, Chuanyang Zhang, Yun Deng, Mingzhi Zhang, Dale Guo*, Fang Deng*. Analysis of the characteristic compounds of Citri Sarcodactylis Fructus from different geographical origins. Phytochemical Analysis, 2022, 33(1): 72–82.
9. Feng Ju, Qixuan Kuang, Qingzhou Li, Lijun Huang, Wenxiu Guo, Leiqiang Gong, Yifei Dai, Lun Wang, Yucheng Gu, Dong Wang, Yun Deng, Dale Guo*. Aureonitol analogues and orsellinic acid esters isolated from Chaetomium elatum and their antineuroinflammatory activity. Journal of Natural Products, 2021, 84(12): 3044–3054.
10. Fan Yang, Hangyi Pu, Aftab Yaseen, Bin Chen, Fu Li, Yucheng Gu, Xiaofei Shen, Mingkui Wang, Dale Guo*, Lun Wang*. Terpenoid and phenolic derivatives from the aerial parts of Elsholtzia rugulosa and their anti-inflammatory activities. Phytochemistry, 2021, 181: 112543.
专利
1. 郭大乐, 邓赟, 秦少容, 陈金凤, 董自亮, 彭涛, 李张宇. 一种HPLC法分离测定藿香正气口服液中多种成分含量的方法.（专利号：ZL 201910524812.9，授权公告号：CN 110231418 B）
2. 郭大乐, 邓赟, 陈金凤, 龚雷强. 地榆中酚苷类化合物的抗炎新用途及其提取分离方法.（专利号：ZL202011364385.1，授权公告号：CN 112274522 B）
3. 郭大乐, 邓赟, 王丽娜, 陈金凤, 谭璐, 旷歧轩. 一种单萜苷类化合物及其在制备抗炎药物上的用途.（申请号：201910735586.9）