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临床中药方向

孔维军

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一、  个人简介

2011年毕业于天下足球网,医学博士。天下足球网,博士研究生导师,博士后合作导师,首都医科大学中医药学院引进人才。现任中国医学科学院药用植物研究所硕士研究生导师,河南大学、天下足球网和江西中医药大学硕士研究生兼职导师。中华中医药学会“青年托举人才”、“协和新星”、中国医学科学院“青年医学人才”、药植所“杰出青年人才”和“优秀指导教师”获得者。担任中华中医药学会中成药分会常务委员,中华中医药学会中药化学分会第四届委员会委员,中国药学会第一届临床中药学专业委员会委员。国家自然科学基金和北京市自然科学基金项目通讯评审专家,教育部学位与研究生教育学位论文评审专家。Journal of Pharmaceutical Analysis、Chinese Medicine、Journal of Analysis and Testing、Acta Materia Medica、Chinese Herbal Medicines、《分析实验室》、《中国药物警戒》、《中南药学》等期刊青年编委;Pharmacological Research-Modern Chinese Medicine、Frontiers in Plant Science、Molecules期刊客座编辑(Guest Editor)。

研究方向为中药质量和安全性评价及临床样本痕量成分检测新方法开发。先后主持国家自然科学基金面上项目(4项)、北京市自然科学基金面上项目(2项)等10余项。以第一/通讯作者在Comprehensive Reviews in Food Science and Food Safety、Trends in Food Science & Technology、Trends in Analytical Chemistry、Biosensors and Bioelectronics、Journal of Hazardous Materials、Analytical Chemistry、Food Chemistry等高水平SCI期刊发表论文90余篇。指导的研究生中多人获得“国家奖学金”及“北京市优秀毕业生”等称号。

二、代表性成果

1、主持承担科研项目

(1)国家自然科学基金面上项目:基于自然光驱动“敏化探针-MOFs纳米酶”可穿戴PEC适配体传感器的中药材上多农药残留现场无毒无损智能检测研究(82274089),20231—202612月,在研。

(2)国家自然科学基金面上项目:基于“复合纳米探针-智能手机荧光读取”微流层析适配体传感器的中药多农药残留现场“掌上检测”研究(81973474),20201月—202312月,在研。

(3)北京市自然科学基金面上项目:基于“重组抗体-金属有机骨架”光电化学传感器的中药材上三嗪类农药“掌上检测”研究(7232265),20231月—202512月,在研。

(4)国家自然科学基金面上项目:基于脱氧核酶和纳米探针双重信号放大的电致化学发光超敏传感器现场检测中药真菌毒素研究(81673593),20171月—202012月,已结题。

(5)国家自然科学基金面上项目:基于“流式微球-适体芯片”的中药真菌毒素现场高通量“掌上检测”体系构建(81473346),20151月—201812月,已结题。

(6)北京市自然科学基金面上项目:基于“基因工程抗体-量子点”微阵列传感器的中药材中酰胺类农药高通量可视化检测研究(7192130),20191月—202112月。

2、发表论文

以第一/通讯作者在Trends in Food Science & Technology、Comprehensive Reviews in Food Science and Food Safety、Journal of Hazardous Materials、Trends in Analytical Chemistry、Biosensors & Bioelectronics、Food Chemistry、Microbiology Spectrum、Chemosphere、Analytical Chemistry、Food Research International、Ecotoxicology and Environmental Safety等国际刊物发表论文90余篇。部分论文如下:

2023

1. Yujiao Hou, Nan Long, Qingbin Xu, Ying Li, Pengyue Song, Minghan Yang, Jiabo Wang, Lidong Zhou, Ping Sheng, Weijun Kong*. Development of a Nafion-MWCNTs and in-situ generated Au nanopopcorns dual-amplification electrochemical aptasensor for ultrasensitive detection of OTA. Food Chemistry, 2023, 403: 134375.

2. Xiaofang Liao, Ying Li, Nan Long, Qingbin Xu, Peng Li, Jiabo Wang, Lidong Zhou, Weijun Kong*. Multi-mycotoxin detection and human exposure risk assessment in medicinal foods. Food Research International, 2023, 164: 112456.

3. Yujiao Hou, Qingbin Xu, Ying Li, Nan Long, Peng Li, Jiabo Wang, Lidong Zhou, Ping Sheng, Weijun Kong*. Ultrasensitive electrochemical aptasensor with Nafion-stabilized f-MWCNTs as signal enhancers for OTA detection. Bioelectrochemistry, 2023, 151: 108399.

2022

1. Yujiao Hou, Boyu Jia, Ping Sheng, Xiaofang Liao, Linchun Shi, Ling Fang, Lidong Zhou, Weijun Kong*. Aptasensors for mycotoxins in foods: Recent advances and future trends. Comprehensive Reviews in Food Science and Food Safety, 2022, 21: 2032-2073.

2. Xin Zhang, Xiaofang Liao, Yujiao Hou, Boyu Jia, Lizhu Fu, Mingxuan Jia, Lidong Zhou, Jinghua Lu, Weijun Kong*. Recent advances in synthesis and modification of carbon dots for optical sensing of pesticides. Journal of Hazardous Materials, 2022, 422, 126881.

3. Nan Long#, Jinxin Liu#, Jiali Liu, Ying Li, Yujiao Hou, Xiaofang Liao, Lidong Zhou, Linchun Shi*, Weijun Kong*. Single-Molecule Real-Time Sequencing to Explore the Mycobiome Diversity in Malt. Microbiology Spectrum, 2022, 10(5): 00511-22.

4.  Ling Fang, Nan Long, Ying Li, Xiaofang Liao, Linchun Shi, Haiping Zhao, Lidong Zhou, Weijun Kong*. Transfer behavior of pesticides from honeysuckle into tea infusions: Establishment of an empirical model for transfer rate prediction. Ecotoxicology and Environmental Safety, 2022, 234: 113377.

5. Mingxuan Jia, Boyu Jia, Xiaofang Liao, Linchun Shi, Zheng Zhang, Miao Liu, Lidong Zhou, Donghui Li, Weijun Kong*. A CdSe@CdS quantum dots based electrochemiluminescence aptasensor for sensitive detection of ochratoxin A. Chemosphere, 2022, 287, 131994.

6. Yujiao Hou, Nan Long, Boyu Jia, Xiaofang Liao, Minghan Yang, Lizhu Fu, Lidong Zhou, Ping Sheng*, Weijun Kong*. Development of a label-free electrochemical aptasensor for ultrasensitive detection of ochratoxin A. Food Control, 2022, 135: 108833.

7. Xin Zhang, Lizhu Fu, Yujiao Hou, Nan Long, Guangqiang Zhu, Xiaofang Liao, Lidong Zhou, Jinghua Lu, Weijun Kong*. A nitrogen-doped carbon dots based fluorescent nanosensor for sensitive assay of Fe3+ ions in Dioscorea opposita Thunb. Industrial Crops & Products, 2022, 177: 114439.

8. Qing Zhang, Linzhi Kang, Pengfei Yue, Linchun Shi, Meng Wang, Lidong Zhou, Haiping Zhao*, Weijun Kong*. Development of a graphene oxide nanosheet and double-stranded DNA structure based fluorescent “signal off” aptasensor for ochratoxin A detection in malt. Food Chemistry: X, 2022, 14: 100308.

9. Lizhu Fu, Yujiao Hou, Haipeng Guo, Chang Liu, Ying Li, Boyu Jia, Lidong Zhou, Weijun Kong*. Gold nanoparticles and nitrogen-doped carbon dots based fluorescent nanosensor for ultrasensitive detection of thiram in hawthorn. Microchemical Journal, 2022, 176: 107253.

2021

1. Ling Fang, Mingxuan Jia, Haiping Zhao, Linzhi Kang, Linchun Shi, Lidong Zhou, Weijun Kong*. Molecularly imprinted polymer-based optical sensors for pesticides in foods: Recent advances and future trends. Trends in Food Science & Technology, 2021, 116, 387-404.

2. Qing Zhang, Ling Fang, Boyu Jia, Nan Long, Linchun Shi, Lidong Zhou, Haiping Zhao, Weijun Kong*. Optical lateral flow test strip biosensors for pesticides: Recent advances and future trends. Trends in Analytical Chemistry, 2021, 144: 116427.

3. Mingxuan Jia, Xiaofang Liao, Ling Fang, Boyu Jia, Miao Liu, Donghui Li, Lidong Zhou, Weijun Kong*. Recent advances on immunosensors for mycotoxins in foods and other commodities. Trends in Analytical Chemistry, 2021, 136: 116193.

4. Boyu Jia, Xiaofang Liao, Chaonan Sun, Ling Fang, Lidong Zhou*, Weijun Kong*. Development of a quantum dot nanobead-based fluorescent strip immunosensor for on-site detection of aflatoxin B1 in lotus seeds. Food Chemistry, 2021, 356: 129614.

5. Xiaofei Liu, Xiaofang Liao, Boyu Jia, Chaonan Sun, Lidong Zhou, Weijun Kong*. Development of a multi-channel magnetic bead micro-probe assay for high-throughput detection of zearalenone in edible and medicinal Coix seed. Food Chemistry, 2021, 347: 128977.

6. Ling Fang, Xiaofang Liao, Qing Zhang, Linchun Shi, Lidong Zhou, Haiping Zhao*, Weijun Kong*. An orthogonal experimental design and QuEChERS based UFLC-MS/MS for multi-pesticides and human exposure risk assessment in Honeysuckle. Industrial Crops & Products, 2021, 164: 113384.

7. Nan Long#, Jinxin Liu#, Xiaofang Liao, Boyu Jia, Jiali Liu, Lidong Zhou, Linchun Shi*, Weijun Kong*. Fungal communities in Nelumbinis semen characterized by high-throughput sequencing. International Journal of Food Microbiology, 2021, 359: 109428.

8. Qiutao Liu, Lingling Jiang, Lihe Xiao, Weijun Kong*. Physico?chemical characteristics and aflatoxins production of Atractylodis Rhizoma to different storage temperatures and humidities. AMB Express, 2021, 11: 155.

9. Yujiao Hou, Boyu Jia, Xiaofang Liao, Lizhu Fu, Xin Zhang, Lidong Zhou, Weijun Kong*. Nanozyme-based biosensors for exogenous contaminant detection in foods. Mini-Reviews in Organic Chemistry, 2021, 18: 1049-1063.

2020

1. Ling Fang, Xiaofang Liao, Boyu Jia, Linchun Shi, Linzhi Kang, Lidong Zhou*, Weijun Kong*. Recent progress in immunosensors for pesticides. Biosensors and Bioelectronics, 2020, 164: 112255.

2. Chaonan Sun, Xiaofang Liao, Pinxuan Huang, Guangzhi Shan, Xiao Ma, Lizhu Fu, Lidong Zhou?, Weijun Kong*. A self-assembled electrochemical immunosensor for ultra-sensitive detection of ochratoxin A in medicinal and edible malt. Food Chemistry, 2020, 315: 126289.

3. Chaonan Sun, Xiaofang Liao, Boyu Jia, Linchun Shi, Dingkun Zhang, Ruilin Wang, Lidong Zhou?, Weijun Kong*. Development of a ZnCdS@ZnS quantum dots-based label-free electrochemiluminescence immunosensor for sensitive determination of aflatoxin B1 in lotus seed. Microchimica Acta, 2020, 187: 236.

4. Xiaofang Liao, Boyu Jia, Chaonan Sun, Linchun Shi, Xi Liu, Lidong Zhou?, Weijun Kong*. Reuse of regenerated immunoaffinity column for excellent clean-up and low-cost detection of trace aflatoxins in malt. Microchemical Journal, 2020, 157, 105007.

5. Xiaofang Liao, Chaonan Sun, Fang Wei, Lidong Zhou*, Weijun Kong*. Exploration of the safe water content and activity control points for medicinal and edible lotus seeds from mildew. AMB Express, 2020, 10: 89.

2019

1. Xiaofei Liu, Guangyao Ying, Xiaofang Liao, Chaonan Sun, Fang Wei, Xiaoyan Xing, Linchun Shi, Yifan Sun, Weijun Kong*, Lidong Zhou*. Cytometric microbead magnetic suspension array for high-throughput ultrasensitive detection of aflatoxin B1. Analytical Chemistry, 2019, 91: 1194-1202.

2. Qiutao Liu, Changbin Xiao, Hongmei Liu, Yichen Hu, Weiying Guo, Weijun Kong*. Sensitive assessment of multi-class mycotoxins residue in Atractylodis rhizoma. Industrial Crops & Products, 2019, 127: 1-10.

3. Weijun Kong, Huijing An, Ji Zhang, Lan Sun, Yao Nan, Aili Song, Lidong Zhou. Development of a high-performance liquid chromatography with tandem mass spectrometry method for identifying common adulterant content in saffron (Crocus sativus L.). Journal of Pharmacy and Pharmacology, 2019, 71, 1864-1870.

4. Fang Wei, Xiaofei Liu, Xiaofang Liao, Linchun Shi, Shuwei Zhang, Jinghua Lu*, Lidong Zhou*, Weijun Kong*. Simultaneous determination of 19 mycotoxins in lotus seed using a multimycotoxin UFLC-MS/MS method. Journal of Pharmacy and Pharmacology, 2019, 71: 1172-1183.

5. Pinxuan Huang, Qiutao Liu, Jiabo Wang, Zhijie Ma, Jinghua Lu*, Weijun Kong?. Development of an economic ultrafast liquid chromatography with tandem mass spectrometry method for trace analysis of multiclass mycotoxins in Polygonum multiflorum. Journal of Separation Science, 2019, 42: 491-500.

2018

1. Xiaofei Liu, Guangyao Ying, Chaonan Sun, Meihua Yang, Lei Zhang, Shanshan Zhang, Xiaoyan Xing, Qian Li, Weijun Kong*. Development of an ultrasonication-assisted extraction based HPLC with a fluorescence method for sensitive determination of aflatoxins in highly acidic Hibiscus sabdariffa. Frontiers in Pharmacology, 2018, 9: 284.

2. Guangyao Ying, Xiaofei Liu, Haiwei Wang, Ruilin Wang, Xinping Ma, Weiying Guo, Weijun Kong*. An economic and green strategy for preventing Chinese medicinal materials from toxigenic fungi: Couplet medicine technique. Industrial Crops & Products, 2018, 124: 429-434.

3. Haiwei Wang, Zhixin Yang, Guangyao Ying, Meihua Yang, Yujiao Nian, Fang Wei, Weijun Kong*. Antifungal evaluation of plant essential oils and their major components against toxigenic fungi. Industrial Crops & Products, 2018, 120: 180-186.

4. Xi Liu, Xiaofei Liu, Pinxuan Huang, Fang Wei, Guangyao Ying, Jinghua Lu*, Lidong Zhou, Weijun Kong*. Regeneration and reuse of immunoaffinity column for highly efficient clean-up and economic detection of ochratoxin A in malt and ginger. Toxins, 2018, 10: 462.

5. Yujiao Nian, Haiwei Wang, Guangyao Ying, Meihua Yang, Ze Wang, Weijun Kong*, Shihai Yang*. Transfer rates of aflatoxins from herbal medicines to decoctions determined by an optimized high-performance liquid chromatography with fluorescence detection method. Journal of Pharmacy and Pharmacology, 2018, 70: 278-288.

3、发表著作

1)《水蛭的现代研究》,2020年,主编。

2)《中药真菌及真菌毒素污染研究与对策》,2020年,编委。

3)《中药质量控制与分析》,2020年,编委。

4)《中药质量生物评价》,2018年,编委。


终审:药学院管理员