陈士林
一、个人简介
陈士林，中国工程院院士、中国医学科学院学部委员，现任天下足球网首席天下足球网、香港浸会大学荣誉天下足球网。兼任CGCM（中药全球化联盟）副主席、中国质量协会中药分会会长、日本东京药科大学客座天下足球网；为教育部“长江学者和创新团队计划”创新团队负责人，曾任中国医学科学院药用植物研究所所长、中国中医科学院中药研究所所长等。担任APSB、Chinese Medicine、CHM、《药学学报》等刊副主编。获得第二届全国创新争先奖章。
陈士林为本草基因组学学科创始人，创建了基于ITS2的中草药DNA条形码鉴定方法体系，完成专著《中国药典中药材DNA条形码标准序列》，从基因层面解决中草药物种真伪鉴定的难题，被评为2016中国十大医学进展；通过全基因组解析提出灵芝为首个中药基原药用模式真菌，被Nature China选为中国最佳研究亮点推介；完成并发表人参、丹参、赤芝、菊花、卷柏、穿心莲、紫芝、紫苏、黄连、红豆杉等全基因组图谱和相关组学研究，成功培育并获批11个中药材新品种证书或良种证书。主编《本草基因组学》并由科学出版社出版，列为全国高等医药院校规划教材；出版《药用植物分子遗传学》，奠定药用植物分子遗传学基础；完成并编著《中国中药材产地生态适宜性数值区划》，避免中药材盲目引种栽培。获吴阶平医药创新奖、Agilent Thought Leadership Award、诺奖之星等荣誉；获国家科技进步二等奖3项。
发表论文500余篇，包括国际著名期刊Nature Plants，Nature Communications，PNAS等，论文被引用3.2万次。H指数86 (Google Scholar)，入选Elsevier公布的全球终身科学影响力榜单。
二、近期主要论文
1. Liang Leng，Zhichao Xu，Bixia Hong，Binbin Zhao，Ya Tian，Can Wang，Lulu Yang，Zhongmei Zou，Lingyu Li，Ke Liu，Wanjun Peng，Jiangning Liu，Zhoujie An，Yalin Wang，Baozhong Duan，Zhigang Hu，Chuan Zheng，Sanyin Zhang，Xiaodong Li，Maochen Li，Zhaoyu Liu，Zenghao Bi，Tianxing He，Baimei Liu，Huahao Fan，Chi Song，Yigang Tong，Shilin Chen*. Cepharanthine analogs mining and genomes of Stephania accelerate anti-coronavirus drug discovery. Nature Communications. 2024 Feb 20; 15(1): 1537.
2. Wei Sun，Qinggang Yin，Huihua Wan，Ranran Gao，Chao Xiong，Chong Xie，Xiangxiao Meng，Yaolei Mi，Xiaotong Wang，Caixia Wang，Weiqiang Chen，Ziyan Xie，Zheyong Xue，Hui Yao，Peng Sun，Xuehua Xie，Zhigang Hu，David R Nelson，Zhichao Xu，Xinxiao Sun，Shilin Chen*. Characterization of the horse chestnut genome reveals the evolution of aescin and aesculin biosynthesis. Nature Communications. 2023 Oct 13; 14(1): 6470.
3. Wei Chen，Chi Song，Liang Leng，Sanyin Zhang，Shilin Chen*.The Application of Artificial Intelligence Accelerates G Protein-Coupled Receptor Ligand Discovery[J]. Engineering, 2024, 32(1): 19-29.
4. Sijie Sun，Xiaofeng Shen，Yi Li，Ying Li，Shu Wang，Rucan Li，Huibo Zhang，Guoan Shen，Baolin Guo，Jianhe Wei，Jiang Xu，Benoit St-Pierre，Shilin Chen*，Chao Sun. Single-cell RNA sequencing provides a high-resolution roadmap for understanding the multicellular compartmentation of specialized metabolism. Nature plants, 2023 Jan; 9(1): 179-190.
5. Baosheng Liao，Xiaofeng Shen，Li Xiang，Shuai Guo，Shiyu Chen，Ying Meng，Yu Liang，Dandan Ding，Junqi Bai，Dong Zhang，Tomasz Czechowski，Yi Li，Hui Yao，Tingyu Ma，Caroline Howard，Chao Sun，Haitao Liu，Jiushi Liu，Jin Pei，Jihai Gao，Jigang Wang，Xiaohui Qiu，Zhihai Huang，Hongyi Li，Ling Yuan，Jianhe Wei，Ian Graham，Jiang Xu，Boli Zhang，Shilin Chen*. Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield. Mol Plant. 2022 Aug 1; 15(8): 1310-1328.
6. Yujun Zhang，Qi Shen，Liang Leng，Dong Zhang，Sha Chen，Yuhua Shi，Zemin Ning，Shilin Chen*. Incipient diploidization of the medicinal plant Perilla within 10,000 years，Nature Communications. volume12, Article number: 5508(2021).
7. Shilin Chen*，Jiang Xu，Chang Liu，Yingjie Zhu，David R Nelson，Shiguo Zhou，Chunfang Li，Lizhi Wang，Xu Guo，Yongzhen Sun，Hongmei Luo，Ying Li，Jingyuan Song，Bernard Henrissat，Anthony Levasseur，Jun Qian，Jianqin Li，Xiang Luo，Linchun Shi，Liu He，Li Xiang，Xiaolan Xu，Yunyun Niu，Qiushi Li，Mira V Han，Haixia Yan，Jin Zhang，Haimei Chen，Aiping Lv，Zhen Wang，Mingzhu Liu，David C Schwartz，Chao Sun. Genome sequence of the model medicinal mushroom Ganoderma lucidum. Nature Communications. 2012 Jun 26; 3: 913.
8. Yifei Liu，Bo Wang，Shaohua Shu，Zheng Li，Chi Song，Di Liu，Yan Niu，Jinxin Liu，Jingjing Zhang，Heping Liu，Zhigang Hu，Bisheng Huang，Xiuyu Liu，Wei Liu，Liping Jiang，Mohammad Murtaza Alami，Yuxin Zhou，Yutao Ma，Xiangxiang He，Yicheng Yang，Tianyuan Zhang，Hui Hu，Michael S Barker，Shilin Chen*，Xuekui Wang，Jing Nie. Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids. Nature Communications. 2021 Jun 2; 12(1): 3276.
9. Shilin Chen，Jingyuan Song， Chao Sun， Jiang Xu，Yingjie Zhu，Rob Verpoorte，Tai Ping Fan.Herbal genomics: Examining the biology of traditional medicines. Science. 2015, 347(6219), S27-S29.
10. China Plant BOL Group，De-Zhu Li，Lian-Ming Gao，Hong-Tao Li，Hong Wang，Xue-Jun Ge，Jian-Quan Liu，Zhi-Duan Chen，Shi-Liang Zhou，Shi-Lin Chen，Jun-Bo Yang，Cheng-Xin Fu，Chun-Xia Zeng，Hai-Fei Yan，Ying-Jie Zhu，Yong-Shuai Sun，Si-Yun Chen，Lei Zhao ，Kun Wang，Tuo Yang，and Guang-Wen Duan.Comparative analysis of a large dataset indicates that internal transcribed spacer (ITS) should be incorportated into the core barcode for seed plants. PNAS, 2011,108:19641-19646.