陈士林
一、个人简介
陈士林 中国工程院院士、中国医学科学院学部委员、天下足球网首席天下足球网，创立了本草基因组学学科体系。任香港浸会大学荣誉天下足球网、教育部“长江学者和创新团队计划”创新团队负责人；兼任日本东京药科大学客座天下足球网。担任APSB、《药学学报》等刊副主编。在Nature, Nature Plants, Nature Communications, PNAS等国内外期刊发表论文500余篇，论文被引用3.2万次，荣获全国创新争先奖章，获国家科技进步二等奖3项。
二、近期主要论文
Liang Leng, Zhichao Xu, Bixia Hong, Binbin Zhao, Ya Tian, CanWang, Lulu Yang, Zhongmei Zou, Lingyu Li, Ke Liu, Wanjun Peng, Jiangning Liu, Zhoujie An, Yalin Wang, Baozhong Duan, ZhigangHu, Chuan Zheng, Sanyin Zhang, Xiaodong Li, Maochen Li, ZhaoyuLiu, Zenghao Bi, Tianxing He, Baimei Liu, Huahao Fan, Chi Song, Yigang Tong, Shilin Chen*. Cepharanthine analogs mining andgenomes of Stephania accelerate anti-coronavirus drug discovery. Nature Communications. 2024 Feb 20;15(1):1537.
Wei Sun, Qinggang Yin, Huihua Wan, Ranran Gao, Chao Xiong, Chong Xie, Xiangxiao Meng, Yaolei Mi, Xiaotong Wang, CaixiaWang, Weiqiang Chen, Ziyan Xie, Zheyong Xue, Hui Yao, PengSun, Xuehua Xie, Zhigang Hu, David R Nelson, Zhichao Xu, XinxiaoSun, Shilin Chen*. Characterization of the horse chestnut genomereveals the evolution of aescin and aesculin biosynthesis. Nature Communications. 2023 Oct 13;14(1):6470.
Wei Chen, Chi Song, Liang Leng, Sanyin Zhang, Shilin Chen*. TheApplication of Artificial Intelligence Accelerates G Protein-CoupledReceptor Ligand Discovery[J]. Engineering, 2024, 32(1):19-29.
Sijie Sun, Xiaofeng Shen, Yi Li, Ying Li, Shu Wang, Rucan Li, Huibo Zhang, Guoan Shen, Baolin Guo, Jianhe Wei, Jiang Xu, Benoit St-Pierre, Shilin Chen*, Chao Sun. Single-cell RNAsequencing provides a high-resolution roadmap for understanding themulticellular compartmentation of specialized metabolism. Nature plants, 2023 Jan; 9(1):179-190.
Baosheng Liao, Xiaofeng Shen, Li Xiang, Shuai Guo, Shiyu Chen, Ying Meng, Yu Liang, Dandan Ding, Junqi Bai, Dong Zhang, TomaszCzechowski, Yi Li, Hui Yao, Tingyu Ma, Caroline Howard, ChaoSun, Haitao Liu, Jiushi Liu, Jin Pei, Jihai Gao, Jigang Wang, XiaohuiQiu, Zhihai Huang, Hongyi Li, Ling Yuan, Jianhe Wei, Ian Graham, Jiang Xu, Boli Zhang, Shilin Chen*. Allele-aware chromosome-levelgenome assembly of Artemisia annua reveals the correlation betweenADS expansion and artemisinin yield. Mol Plant. 2022 Aug1;15(8):1310-1328.
Yujun Zhang, Qi Shen, Liang Leng, Dong Zhang, Sha Chen, YuhuaShi, Zemin Ning, Shilin Chen*. Incipient diploidization of themedicinal plant Perilla within 10, 000 years, Nature Communications, volume12, Article number:5508(2021).
Shilin Chen*, Jiang Xu, Chang Liu, Yingjie Zhu, David R Nelson, Shiguo Zhou, Chunfang Li, Lizhi Wang, Xu Guo, Yongzhen Sun, Hongmei Luo, Ying Li, Jingyuan Song, Bernard Henrissat, AnthonyLevasseur, Jun Qian, Jianqin Li, Xiang Luo, Linchun Shi, Liu He, Li Xiang, Xiaolan Xu, Yunyun Niu, Qiushi Li, Mira V Han, HaixiaYan, Jin Zhang, Haimei Chen, Aiping Lv, Zhen Wang, MingzhuLiu, David C Schwartz, Chao Sun. Genome sequence of the modelmedicinal mushroom Ganoderma lucidum. Nature Communications. 2012 Jun 26;3:913.
Yifei Liu, Bo Wang, Shaohua Shu, Zheng Li, Chi Song, Di Liu, Yan Niu, Jinxin Liu, Jingjing Zhang, Heping Liu, Zhigang Hu, Bisheng Huang, Xiuyu Liu, Wei Liu, Liping Jiang, MohammadMurtaza Alami, Yuxin Zhou, Yutao Ma, Xiangxiang He, YichengYang, Tianyuan Zhang, Hui Hu, Michael S Barker, Shilin Chen*, Xuekui Wang, Jing Nie. Analysis of the Coptis chinensis genomereveals the diversification of protoberberine-type alkaloids. Nature Communications. 2021 Jun 2;12(1):3276.
Shilin Chen, Jingyuan Song, Chao Sun, Jiang Xu, Yingjie Zhu, Rob Verpoorte, Tai Ping Fan.Herbal genomics: Examining the biologyof traditional medicines. Science 2015, 347(6219), S27-S29.
China Plant BOL Group, De-Zhu Li, Lian-Ming Gao, Hong-Tao Li, Hong Wang, Xue-Jun Ge, Jian-Quan Liu, Zhi-Duan Chen, Shi-LiangZhou, Shi-Lin Chen, Jun-Bo Yang, Cheng-Xin Fu, Chun-Xia Zeng, Hai-Fei Yan, Ying-Jie Zhu, Yong-Shuai Sun, Si-Yun Chen, Lei Zhao, Kun Wang, Tuo Yang, and Guang-Wen Duan.Comparative analysisof a large dataset indicates that internal transcribed spacer (ITS) shouldbe incorportated into the core barcode for seed plants. PNAS, 2011, 108:19641-19646.